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صفحهای تازه حاوی «Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder that is characterized by stereotyped behavior and deficits in communication and social interaction. Autism spectrum disorder affects 3.4–6.7 per 1,000 children. Boys are four times more likely than girls to have Autism spectrum disorder. The core features of Autism spectrum disorder patients are social communication deficits and repetitive sensory–motor behavi...» ایجاد کرد |
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A ketogenic diet is a high-fat, appropriate-protein, and low-carbohydrate diet that has a positive effect on energy metabolism. For example, a ketogenic diet increases the levels of adenosine triphosphate (ATP) and enzymes associated with mitochondrial metabolic pathways and enhances mitochondrial biogenesis. Acetyl-CoA is converted to ketone bodies under the effects of d-β-hydroxybutyrate dehydrogenase, acetoacetate succinyl-CoA transferase, and acetoacetyl-CoA-thiolase. Ketone bodies, including β-hydroxybutyrate, acetoacetate, and acetone, function as fuels under fasting or starvation conditions and cross the blood–brain barrier (BBB) to feed the brain. These molecules also prevent mitochondrial permeability transition and attenuate reactive oxygen species (ROS). Therefore, ketone bodies have neuroprotective effects in the central nervous system (CNS). A ketogenic diet is a significantly effective treatment for epilepsy. Refractory epilepsy patients aged 1–18 years treated with a ketogenic diet for 4 months had a 56% reduction in mean seizure frequency. A ketogenic diet may also improve some core autistic features and comorbidities of Autism spectrum disorder, but data of clinical studies of a ketogenic diet as a treatment for Autism spectrum disorder are very limited. The present review examined the role of a ketogenic diet in Autism spectrum disorder treatment and discussed the underlying mechanisms. | A ketogenic diet is a high-fat, appropriate-protein, and low-carbohydrate diet that has a positive effect on energy metabolism. For example, a ketogenic diet increases the levels of adenosine triphosphate (ATP) and enzymes associated with mitochondrial metabolic pathways and enhances mitochondrial biogenesis. Acetyl-CoA is converted to ketone bodies under the effects of d-β-hydroxybutyrate dehydrogenase, acetoacetate succinyl-CoA transferase, and acetoacetyl-CoA-thiolase. Ketone bodies, including β-hydroxybutyrate, acetoacetate, and acetone, function as fuels under fasting or starvation conditions and cross the blood–brain barrier (BBB) to feed the brain. These molecules also prevent mitochondrial permeability transition and attenuate reactive oxygen species (ROS). Therefore, ketone bodies have neuroprotective effects in the central nervous system (CNS). A ketogenic diet is a significantly effective treatment for epilepsy. Refractory epilepsy patients aged 1–18 years treated with a ketogenic diet for 4 months had a 56% reduction in mean seizure frequency. A ketogenic diet may also improve some core autistic features and comorbidities of Autism spectrum disorder, but data of clinical studies of a ketogenic diet as a treatment for Autism spectrum disorder are very limited. The present review examined the role of a ketogenic diet in Autism spectrum disorder treatment and discussed the underlying mechanisms. | ||
A ketogenic diet is a dietary intervention therapy in neurological disorders such as epilepsy and Autism spectrum disorder. A ketogenic diet may be an effective therapy for ASD because it might improve Autism spectrum disorder core symptoms and could benefit its comorbidities, including seizures. The efficiency of a ketogenic diet must be monitored using urinary ketones and serum beta-hydroxybutyrate (BHB). Some evidence showed that a ketogenic diet improved the core features of Autism spectrum disorder patients (Table 1). El-Rashidy et al. showed that a ketogenic diet improved autistic manifestations, which was demonstrated as improved scores on the Autism Treatment Evaluation Test (ATEC) scales and the Childhood Autism Rating Scale (CARS), especially sociability improvement. Lee et al. also reported that a modified ketogenic gluten-free diet with supplemental medium-chain triglycerides (MCTs) improved the social affect subdomain and total autism diagnostic observation schedule, 2nd edition (ADOS-2) scores, but it did not affect the restricted and repetitive behavior scores. A ketogenic diet improved social exploration and social interactions in an animal model of Autism spectrum disorder. It also ameliorates the comorbidities of Autism spectrum disorder more efficiently than the core symptoms of Autism spectrum disorder. A ketogenic diet improved the social communication of one of six Autism spectrum disorder patients, but it reduced the comorbidities of all six Autism spectrum disorder patients, including attention deficit hyperactivity disorder (ADHD), compulsive behavior, preoccupation with parts of objects, and abnormal sleep. It also decreased the frequency of seizures. A case report of an Autism spectrum disorder child found that a ketogenic diet improved the electroencephalogram results and increased the child's intelligence quotient. Although a ketogenic diet-induced decrease in seizures will lead to a better quality of life in patients with epilepsy, including Autism spectrum disorder, it is not associated with improvements in behaviors in Autism spectrum disorder patients. Antiepileptic drugs do not have a large effect on the behavioral symptoms in Autism spectrum disorder. | |||