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A ketogenic diet is a dietary intervention therapy in neurological disorders such as epilepsy and Autism spectrum disorder. A ketogenic diet may be an effective therapy for ASD because it might improve Autism spectrum disorder core symptoms and could benefit its comorbidities, including seizures. The efficiency of a ketogenic diet must be monitored using urinary ketones and serum beta-hydroxybutyrate (BHB)<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863039/A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder]</ref>.autism spectrum disorder]</ref>. Some evidence showed that a ketogenic diet improved the core features of Autism spectrum disorder patients | A ketogenic diet is a dietary intervention therapy in neurological disorders such as epilepsy and Autism spectrum disorder. A ketogenic diet may be an effective therapy for ASD because it might improve Autism spectrum disorder core symptoms and could benefit its comorbidities, including seizures. The efficiency of a ketogenic diet must be monitored using urinary ketones and serum beta-hydroxybutyrate (BHB)<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863039/A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder]</ref>.autism spectrum disorder]</ref>. Some evidence showed that a ketogenic diet improved the core features of Autism spectrum disorder patients | ||
A Ketogenic Diet may improve social behavior in Autism spectrum disorder via normalizing GABA, improving mitochondrial function, ameliorating inflammatory activity and oxidative stress in the brain, inhibiting the mTOR signaling pathway, and modulating the gut microbiota<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344784/ Reduced GABA and altered somatosensory function in children with autism spectrum disorder]</ref> | A Ketogenic Diet may improve social behavior in Autism spectrum disorder via normalizing GABA, improving mitochondrial function, ameliorating inflammatory activity and oxidative stress in the brain, inhibiting the mTOR signaling pathway, and modulating the gut microbiota<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344784/ Reduced GABA and altered somatosensory function in children with autism spectrum disorder]</ref> | ||
. However, the effects of Ketogenic Diet vary widely between Autism spectrum disorder patients, and the underlying mechanisms are not known. Autism spectrum disorder children may also reject Ketogenic Diet food because of their selective eating habits, which complicates the introduction of a Ketogenic Diet to Autism spectrum disorder patients. Some studies showed that Autism spectrum disorder children have nutrient deficiencies, including vitamin D and folic acid<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837386/ Chemicals, nutrition, and autism spectrum disorder: a mini-review]</ref>. Long-term treatment of a Ketogenic Diet likely aggravates the nutritional deficiency. The benefits of a long-term Ketogenic Diet treatment in Autism spectrum disorder children are not known. Therefore, more studies with larger samples and long-term Ketogenic Diet treatment are needed to demonstrate the beneficial effects of a Ketogenic Diet and its side effects in children with Autism spectrum disorder. | . However, the effects of Ketogenic Diet vary widely between Autism spectrum disorder patients, and the underlying mechanisms are not known. Autism spectrum disorder children may also reject Ketogenic Diet food because of their selective eating habits, which complicates the introduction of a Ketogenic Diet to Autism spectrum disorder patients. Some studies showed that Autism spectrum disorder children have nutrient deficiencies, including vitamin D and folic acid<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837386/ Chemicals, nutrition, and autism spectrum disorder: a mini-review]</ref>. Long-term treatment of a Ketogenic Diet likely aggravates the nutritional deficiency. The benefits of a long-term Ketogenic Diet treatment in Autism spectrum disorder children are not known. Therefore, more studies with larger samples and long-term Ketogenic Diet treatment are needed to demonstrate the beneficial effects of a Ketogenic Diet and its side effects in children with Autism spectrum disorder. | ||